Former CIA black-ops agent Frank Moses (Bruce Willis) and his old partner, Marvin Boggs (John Malkovich), are caught in the grip of retirement – but that soon changes when a powerful Cold War weapon known as Nightshade resurfaces decades after its disappearance. With assassins hot on their trail, Frank and his team set out to find the one scientist (Anthony Hopkins) who can unravel the mystery of Nightshade and help them save themselves – and the world.